Prevention of adrenaline-induced pulmonary edema by stem bromelain in rabbits and analysis of the hemodynamic changes.

In the course of our researches on the preventive action of stem bromelain (BRM), a protease obtained from pine apple plant, against the adrenaline induced pulmonary edema in rats, it was noticed that a pretreatment with this enzyme also inhibited the occur rence of the circulatory and respiratory changes caused by adrenaline which were remark able in the nontreated animals (1). This suggested that further analysis of the differences in the hemodynamic pattern might throw light on the mechanism of the pulmonary edema and the mode of action of BRM. In the present study, we made an investigation of the effects of BRM in rabbits and analyzed the data to locate the sites of action from the hemo dynamic point of view.